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A new polyketide synthase nonribosomal peptide synthetase hybrid metabolite from plant endophytic fungus Periconia sp. |
De-Wu Zhanga,b, Xiao-Yu Taoa, Ji-Mei Liua, Ri-Dao Chena, Min Zhanga, Xiao-Mei Fangb, Li-Yan Yub, Jun-Gui Daia |
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;
b Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China |
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Abstract A new polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) hybrid metabolite, named pericoannosin B (1), was isolated from endophytic fungus Periconia sp. F-31 of the medicinal plant Annona muricata. The structure and absolute configuration were elucidated by means of extensive spectroscopic analyses (HRMS, NMR, IR, and CD).
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Received: 15 December 2015
Published: 02 March 2016
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Fund:This work was financially supported by the National Natural Science Foundation of China (Nos. 31170041 and 81402835), the National High Technology Research and Development Program of China (No. 2012AA091606), and The National Infrastructure of Microbial Resources (No. NIMR-2015-3). |
Corresponding Authors:
Li-Yan Yu, Jun-Gui Dai
E-mail: yly@cpcc.ac.cn;jgdai@imm.ac.cn
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