Metal complexes of anthranilic acid derivatives: A new class of noncompetitive <em>α</em>-glucosidase inhibitors

doi:10.1016/j.cclet.2016.01.052

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Abstract Metal complexes of anthranilic acid derivatives that constitute a novel class of non-sugar-type α-glucosidase inhibitors were synthesized and assessed in vitro for inhibitory activity. All of the Ag(Ⅰ) complexes (9-16) inhibited α-glucosidase at the nanomolar scale, while 3,5-dichloroanthranilic acid silver(Ⅰ) (9) was the most potent (IC₅₀=3.21 nmol/L). Analysis of the kinetics of enzyme inhibition indicated that the mechanism of the newly prepared silver complexes was noncompetitive. The structure-activity relationships were also analyzed, and they are discussed in this report.

Key words： α-Glucosidase Anthranilic acid derivatives Metal complexes Noncompetitive inhibitors

Received: 21 July 2015 Published: 10 February 2016

Corresponding Authors: Jing-Wei Zheng E-mail: zhengjnw@mail2.sysu.edu.cn

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http://www.chinchemlett.com.cn/EN/10.1016/j.cclet.2016.01.052 OR http://www.chinchemlett.com.cn/EN/Y2016/V27/I05/627

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