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| Efficient synthesis of 2-arylquinazolines via copper-catalyzed dual oxidative benzylic C-H aminations of methylarenes |
| Li-Yan Liu, Yi-Zhe Yan, Ya-Jie Bao, Zhi-Yong Wang |
| Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology, University of Science and Technology of China, Hefei 230026, China |
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Abstract A novel copper-catalyzed dual oxidative benzylic C-H aminations of methylarenes with 2- aminobenzoketones in the presence of ammonium acetate was developed. This reaction represents a new avenue for 2-arylquinazolines with good yields. A key intermediate was detected and the kinetics isotope effect (KIE) indicated that C-H bond cleavage was the rate-determining step.
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Received: 05 May 2015
Published: 07 July 2015
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| Fund:We are grateful to the National Nature Science Foundation of China (Nos. 2127222, 91213303, 21172205, 21432009, 21472177). |
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Corresponding Authors:
Zhi-Yong Wang
E-mail: zwang3@ustc.edu.cn
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