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| Direct C-H amination for indole synthesis from N-Ts-2-Styrylaniline derivatives catalyzed by copper salt |
| Di Chen, Han-Jie Mo, Ding-Ben Chen, Jian-Guo Yang |
| School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou 317000, China |
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Abstract A direct C-H amination reaction of N-Ts-2-Styrylaniline derivatives to realize the synthesis of indole derivatives was developed in the presence of copper salt. A variety of N-Ts-2-Styrylaniline derivatives were transformed into the corresponding indole products in good to excellent yield under mild conditions with the oxidation of potassium persulfate.
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Received: 07 February 2015
Published: 18 April 2015
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| Fund:This work was financially supported by the National Natural Science Foundation of China (Nos. 21272169, 21302135), the Key Innovation Team of Science & Technology in Zhejiang Province (No. 2010R50018-10), the Science and Technology Bureau of Taizhou (No. 08KY10) and the Key Disciplines of Applied Chemistry of Zhejiang Province, Taizhou University. |
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Corresponding Authors:
Jian-Guo Yang
E-mail: yjg@tzc.edu.cn
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