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| Synthesis and structures of malonate derivative-calix[4]arene conjugates |
| Wen-Jing Hua, Ming-Liang Mab, Yahu A. Liuc, Jiu-Sheng Lia, Biao Jianga, Ke Wena,b,d |
a Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China;
b Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062, China;
c Medicinal Chemistry, ChemBridge Research Laboratories Inc., San Diego, CA 92127, USA;
d School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China |
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| Guide A series of novel malonate derivatives-calix[4]arene conjugates were synthesized through Knoevenagel condensation reaction, and the structures of these functionalized calix[4]arenes have been determined |
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Abstract A series of malonate derivatives-calix[4]arene conjugates were synthesized through Knoevenagel condensation reaction between formyl-tetrapropoxycalix[4]arene and malonate derivatives. The structures of the resulting malonate derivative functionalized calix[4]arenes were characterized by NMR spectroscopy, mass spectrometry and even single crystal X-ray diffraction analysis.
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Received: 31 March 2015
Published: 15 May 2015
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| Fund: Financial support from the National Natural Science Foundation of China (No. 21371177) is acknowledged. |
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Corresponding Authors:
Ming-Liang Ma, Ke Wena
E-mail: mlma@brain.ecnu.edu;wenk@sari.ac.cn
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