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| Convenient synthesis of spiro[indoline-3,4'-pyrano[2,3-c]pyrazole] and spiro[acenaphthyl-3,4'-pyrano[2,3-c]pyrazoles] via fourcomponent reaction |
| Chao Wang, Yan-Hong Jiang, Chao-Guo Yan |
| College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China |
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| Guide The base promoted four-component reaction of hydrated hydrazine, dimethyl acetylenedicarboxylate, isatines and malononitrile (ethyl cycanoacetate) in ethanol afforded polysubstituted spiro[indoline-3,4‘-pyrano[2,3-c]pyrazoles] and spiro[acenaphthyl-3,4-pyrano[2,3-c]pyrazoles] |
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Abstract The domino four-component reaction of hydrated hydrazine, dimethyl acetylenedicarboxylate, isatin and malononitrile or ethyl cycanoacetate in ethanol in the presence of triethylamine afforded the polysubstituted spiro[indoline-3,4'-pyrano[2,3-c]pyrazole] derivatives in satisfactory yields. Under similar conditions, the four-component reaction containing acenaphthenequinone also resulted in the spiro[acenaphthyl-3,4'-pyrano[2,3-c]pyrazole] in good yields.
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Received: 03 March 2015
Published: 15 May 2015
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| Fund: This work was financially supported by the National Natural Science Foundation of China (No. 21172189) and the Priority Academic Program Development of Jiangsu Higher Education Institutions, China. We thanked Analysis and Test Center of Yangzhou University providing all analytical instruments. |
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Corresponding Authors:
Chao-Guo Yan
E-mail: cgyan@yzu.edu.cn
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