Direct amination of pyrimidin-2-yl tosylates with aqueous ammonia under metal-free and mild conditions

doi:10.1016/j.cclet.2015.01.034

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Abstract

Ametal-free synthesis of pyrimidine functionalized primary amines via direct amination of pyrimidin-2-yl tosylate with aqueous ammonia has been developed under mild conditions. The desired products pyrimidin-2-amines can be generated in excellent yields in PEG-400, without any catalysts or other additives.

Key words： Ammonia 2-Aminopyrimidines Pyrimidin-2-yl tosylate PEG-400

Received: 03 December 2014 Published: 07 February 2015

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Financial support was provided by the financial support from the NSFC (Nos. 21362032 and 21362031), the Natural Science Foundation of Gansu Province (No. 1208RJYA083), Gansu Provincial Department of Finance and the Education Department of Gansu Province (No. 2013B-010).

Corresponding Authors: Zheng-Jun Quan, Xi-Cun Wang E-mail: quanzhengjun@htmail.com;wangxicun@nwnu.edu.cn

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http://www.chinchemlett.com.cn/EN/10.1016/j.cclet.2015.01.034 OR http://www.chinchemlett.com.cn/EN/Y2015/V26/I06/667

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