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| Microwave-assisted effi cient synthesis of azlactone derivatives using 2-aminopyridine-functionalized sphere SiO2 nanoparticles as a reusable heterogeneous catalyst |
| Akbar Mobinikhaledia, Hassan Moghanianb, Samira Pakdela |
a Department of Chemistry, Faculty of Science, Arak University, Arak 38156-8-8349, Iran;
b Department of Chemistry, Dezful Branch, Islamic Azad University, Dezful, Iran |
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Abstract In the present work, the highly efficient Erlenmeyer synthesis of azlactones catalyzed by 2- aminopyridine, supported on nano-sphere SiO2 is reported. First, the silica nanoparticles were modified with triethoxysilylpropyl chloride and then 2-aminopyridine was attached to the support via covalent linkages. This new heterogenized catalyst was used for efficient microwave-assisted synthesis of azlactone derivatives with Ac2O as a condensing agent under solvent-free conditions. The present method offers advantages including high yields, short reaction times and simple work-up. Also, the catalyst can be easily recycled and reused several times, which makes this method attractive, economic and environmentally-benign.
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Received: 10 January 2014
Published: 17 December 2014
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Corresponding Authors:
Hassan Moghanian
E-mail: moghanian@gmail.com
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