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| One-pot synthesis of novel pyrido[2,3-d]pyrimidines using HAp-encapsulated-γ-Fe2O3 supported sulfonic acid nanocatalyst under solvent-free conditions |
| Moona Mohsenimehra, Manouchehr Mamaghania, Farhad Shirinia, Mehdi Sheykhana, Fatemeh Azimian Moghaddamb |
a Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, Iran;
b Department of Chemistry, Islamic Azad University, Rasht Branch, Iran |
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Abstract Novel pyrido[2,3-d]pyrimidine derivatives were synthesized through a one-pot three-component approach using HAp-encapsulated-γ-Fe2O3 [γ-Fe2O3@HAp-SO3H] catalyzed condensation of 6-amino-2-(methylthio or ethylthio)pyrimidin-4(3H)-one, Meldrum's acid and aryl aldehydes at 60℃ and under solvent-free conditions. In this protocol the use of nanocatalyst provided a green, useful and rapid method to generate the products in short reaction times and excellent yields (88%-94%).
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Received: 21 February 2014
Published: 29 April 2014
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Corresponding Authors:
Manouchehr Mamaghani
E-mail: m-chem41@guilan.ac.ir, mchem41@gmail.com
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