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| Iridoid glycosides from the roots of Scrophularia ningpoensis Hemsl |
| Ling-Juan Zhua,b, Cheng Qiaoa,b, Xiu-Yu Shena,b, Xue Zhanga,b, Xin-Sheng Yaoa,b,c |
a College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;
b Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China;
c Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China |
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Abstract Two new iridoid glycosides, named scrophularianoids A (1) and B (2), were isolated from the roots of Scrophularia ningpoensis. The chemical structures were established on the basis of extensive analyses of spectroscopic data. Compounds 1 and 2 were inactive in our preliminary in vitro myocardial protective bioassay.
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Received: 03 March 2014
Published: 14 May 2014
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Corresponding Authors:
Xue Zhang, Xin-Sheng Yao
E-mail: syzxalice@163.com;tyaoxs@jnu.edu.cn
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| [11] |
S. Damtoft, S.R. Jensen, B.J. Nielsen, 13C and 1H NMR spectroscopy as a tool in the configurational analysis of iridoid glucosides, Phytochemistry 20 (1981) 2717-2732.
|
| [3] |
A.T. Nguyen, J. Fontaine, H. Malonne, et al., A sugar ester and an iridoid glycoside from Scrophularia ningpoensis, Phytochemistry 66 (2005) 1186-1191.
|
| [6] |
L.Q. Zhang, F.J. Guo, S.C. Wang, Y.M. Li, A new triterpenoid tetrasaccharide from the root of Scrophularia ningpoensis, Acta Pharm. Sin. 47 (2012) 1358-1362.
|
| [9] |
T. Tanaka, T. Nakashima, T. Ueda, et al., Facile discrimination of aldose enantiomers by reversed-phase HPLC, Chem. Pharm. Bull. 55 (2007) 899-901.
|
| [2] |
Y.M. Li, S.H. Jiang, W.Y. Gao, D.Y. Zhu, Iridoid glycosides from Scrophularia ningpoensis, Phytochemistry 50 (1999) 101-104.
|
| [5] |
Y.M. Li, S.H. Jiang, W.Y. Gao, D.Y. Zhu, Phenylpropanoid glycosides from Scrophularia ningpoensis, Phytochemistry 54 (2000) 923-925.
|
| [1] |
Naijing University of Chinese Medicine, Dictionary of Traditional Chinese Medicine, 2nd ed., Shanghai Scientific and Technical Publishers, Shanghai, 2006, pp. 1060-1063.
|
| [7] |
L.J. Zhu, Y.L. Hou, X.Y. Shen, et al., Monoterpene pyridine alkaloids and phenolics from Scrophularia ningpoensis and their cardioprotective effect, Fitoterapia 88 (2013) 44-49.
|
| [8] |
B. Chen, Y. Liu, H.W. Liu, et al., Iridoid and aromatic glycosides from Scrophularia ningpoensis Hemsl. and their inhibition of [Ca2+]i increase induced by KCl, Chem. Biodivers. 5 (2008) 1723-1735.
|
| [4] |
B. Chen, N.L. Wang, J.H. Huang, et al., Iridoid and phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl., Asian J. Tradit. Med. 2 (2007) 118-123.
|
| [10] |
E.K. Robert, R.S. Frank, Trans-fused iridoid glycosides from Penstemon mucronatus, Phytochemistry 49 (1998) 2413-2415.
|
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