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| L-ProT catalyzed highly regioselective N-alkoxyalkylation of purine rings with vinyl ethers |
| Jian-Jun Li, Xing-Xing Gui |
| Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China |
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Abstract An efficient and regioselective synthesis of N-9 alkoxyalkylated purine nucleoside derivatives was achieved via the N-alkoxyalkylation of purine rings with vinyl ethers catalyzed by L-ProT. The advantages of this protocol include good to excellent yield, mild reaction condition, and simple manipulation. A plausible mechanism for the transformation was given.
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Received: 17 February 2014
Published: 30 April 2014
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| Fund: We are grateful to the Natural Science Foundation of Zhejiang Province (No. LY13B020015) and Zhejiang Key Innovation Team of Green Pharmaceutical Technology (No. 2012R10043-07) for financial support. |
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Corresponding Authors:
Jian-Jun Li
E-mail: lijianjun@zjut.edu.cn
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