A simple synthetic approach for the transformation of (<em>S</em>)-Ugi’s amine

doi:10.1016/j.cclet.2014.06.009

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Abstract

A simple synthetic approach for the transformation of (S)-Ugi's amine, another configuration of (R)-Ugi's amine, one of the most widely used intermediate in the preparation of chiral ferrocene-based ligands, has been developed via esterification using anhydride, alkaline hydrolysis and active manganese dioxide oxidation, and the corresponding ferrocenyl ketone was afforded in good yields.

Key words： (S)-Ugi’s amine Transformation Esterification Hydrolysis Oxidation

Received: 08 April 2014 Published: 19 June 2014

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We are grateful for financial support from the National Natural Science Foundation of China (No. 20972123) and Wuhan Science and Technology Bureau.

Corresponding Authors: Yong-Cun Shen E-mail: yongcunshen@163.com

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