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| A facile synthesis of cajaninstilbene acid and its derivatives |
| Qi Chen, Kuo Lu, Chang Zheng, Xiao-Fang Xu, Jing Lin, Wei-Min Chen |
| College of Pharmacy, Jinan University, Guangzhou 510632, China |
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| Guide A facile synthesis of cajaninstilbene and its derivatives by using a building block has been developed. |
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Abstract A four-step synthesis of methyl 6-formyl-2-hydroxy-4-methoxy-3-(3-methylbut-2-en-1-yl)benzoate (11) that can be used as building block for a facile synthesis of cajaninstilbene acid and its derivatives is reported. The synthesis of cajaninstilbene acid was accomplished in six steps with an overall yield of 20% starting from commercial materials by a synthesis whose key steps are TiCl4-mediated [3 + 3] cyclization and McMurry coupling.
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Received: 28 January 2019
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| Fund:This work was supported by the National Natural Science Foundation of China (No. 81673336). |
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Corresponding Authors:
Jing Lin, Wei-Min Chen
E-mail: linjing-jnu@163.com;twmchen@jnu.edu.cn
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