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| One-pot photoreduction to prepare NIR-absorbing plasmonic gold nanoparticles tethered by amphiphilic polypeptide copolymer for synergistic photothermal-chemotherapy |
| Siqi Yanga, Linzhu Zhoua, Yue Sua, Rong Zhangb, Chang-Ming Donga,b |
a School of Chemistry and Chemical Engineering, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University, Shanghai 200240, China;
b Joint Research Center for Precision Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai Fengxian Central Hospital, Shanghai 201400, China |
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| Guide We developed one-pot photoreduction strategy to fabricate the NIR-absorbing plasmonic PLC-b-PEO@Au NPs. It possessed strong NIR absorption at 700-1100 nm, an ultrahigh photothermal conversion efficiency of 62.1%, and good photostability. |
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Abstract We developed one-pot photoreduction strategy to prepare near infrared light (NIR)-absorbing plasmonic gold nanoparticles (Au NPs) tethered by amphiphilic polypeptide copolymer poly(L-cysteine)-b-poly (ethylene oxide) (PLC-b-PEO). The PLC-b-PEO@Au NPs possessed strong NIR absorption at 700-1100 nm and ultrahigh photothermal conversion efficiency of 62.1%. Upon the NIR irradiation (808 nm, 2 W/cm2, 5 min), the PLC-b-PEO@Au NPs (1 mg/mL) sharply attained an elevation of 30.8℃ and the hyperthermia effect could efficiently kill cancer cells in vitro. As for the PT-CT treatment, the doxorubicin (DOX)-loaded nanoparticles of DOX-PLC-b-PEO@Au NPs gave a combination index of 0.9 compared to single chemotherapy (CT) or photothermal therapy (PT), demonstrating a synergistic effect.
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Received: 29 December 2017
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| Fund:The National Natural Science Foundation of China (No. 21474061) and The Innovation Fund (No. IFPM2016B004) of Shanghai Jiao Tong University & Affiliated Sixth People's Hospital South Campus are appreciated. |
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Corresponding Authors:
Rong Zhang, Chang-Ming Dong
E-mail: rongzhang@163.com;cmdong@sjtu.edu.cn
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