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| Three new pyrrolizidine alkaloids derivatives from Liparis nervosa |
| Shuai Huang, De-Xin Zhong, Lian-Hai Shan, Ye-Zi Zheng, Zhi-Kuan Zhang, Ya-Heng Bu, Hong-Wen Ma, Xian-Li Zhou |
| School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China |
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Abstract Three new pyrrolizidine alkaloids, nervosine VII (1), nervosine VIII (2) and nervosine IX (3) were isolated from the whole plant extract of Liparis nervosa. Their structures were elucidated by extensive spectroscopic analyses (including 1D, 2D NMR, and HR-ESI-MS) and chemical methods. Compounds 1-3 were evaluated for their cytotoxic activity against A549, MCF-7 and H460 human cancer cell lines.
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Received: 19 August 2015
Published: 08 January 2016
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| Fund:This work was financially supported by the National Natural Science Foundation of China (Nos. 81402803, 31171695), the Science and Technology Support Programs of Sichuan Province (No. 2013SZ0083, 2015GZ0233), the Research Foundation for Educational Commission of Sichuan Province (No. 15TD0048), the Fundamental Research Funds for Central Universities (No. 2682014RC15), and national undergraduate training programs for innovation and entrepreneurship (No. 201510613065). |
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Corresponding Authors:
Xian-Li Zhou
E-mail: xxbiochem@163.com
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