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| Electro-oxidation of paracetamol in the presence of malononitrile: Application for green, efficient, none-catalyst, simple and one-pot electro-synthesis of new paracetamols |
| Alireza Asghari, Mohsen Ameri, Ali Akbar Ziarati, Sepideh Radmannia, Ali Amoozadeh, Behruz Barfi, Leila Boutorabi |
| Department of Chemistry, Semnan University, Semnan 35195-363, Iran |
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Abstract Electrochemical oxidation of paracetamol has been studied in the presence of malononitrile as a nucleophile in a phosphate buffer solution (0.15 mol/L, pH 7), using cyclic voltammetric techniques. The results indicated that the N-acetyl-p-benzoquinone-imine derived from paracetamol participates in a 1,4-Michael-type addition reaction with the malononitrile to form the corresponding paracetamol derivatives (6a, 7a). The present study has led to the development of a simple, green, non-catalyst and one-pot electrochemical method with high atom economy under mild conditions.
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Received: 25 December 2014
Published: 06 April 2015
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Corresponding Authors:
Alireza Asghari
E-mail: aasghari@semnan.ac.ir
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