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| A novel method for the synthesis of sulfur substitutedcyclopyrophosphate of cADPR analogs |
| Ren-Min Wu, Na Qi, Yu-Wen Jia, Zhu Guan, Liang-Ren Zhang, Li-He Zhang, Zhen-Jun Yang |
| State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China |
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Abstract A facile and efficient protocol for the synthesis of sulfur substituted-cyclopyrophosphate of cIDPRE (PS1-cIDPRE) was developed. The key step was the cyclization process which was completed by the sulfur substituted cyclization precursor 1b via the one-pot phosphoramidite strategy.
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Received: 03 June 2014
Published: 23 July 2014
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| Fund: Weare grateful for scientific research funding from the National Natural Science Foundation of China (Nos. 21332010, 21172010, 21002004). |
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Corresponding Authors:
Zhen-Jun Yang
E-mail: yangzj@bjmu.edu.cn
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