Rhodium-catalyzed cross-coupling reactions of unactivated primary alkyl chlorides with diboron reagents have been developed as practical methods for the synthesis of alkylboronic esters. These reactions expand the concept and utility of Rh(I)-catalyzed cross-coupling of aliphatic electrophiles.
Received: 11 September 2013
Published: 10 January 2014
This study was supported by the National Basic Research Program of China (973 Program; No. 2013CB932800), NSFC (No. 20972148), and CAS (No. KJCX2-EW-J02). We also thank the support of China Postdoctoral Science Foundation (Nos. 2011M500289, 2012T50078).