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| Reversible photoswitching aggregation and dissolution of spiropyranfunctionalized copolymer and light-responsive FRET process |
| Lei-Xiao Yu, Yang Liu, Si-Chong Chen, Yue Guan, Yu-Zhong Wang |
| Center for Degradable and Flame-Retardant Polymeric Materials, State Key Laboratory of Polymer Materials Engineering, College of Chemistry, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), Sichuan University, Chengdu 610064, China |
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Abstract Well-defined, reversibly light-responsive amphiphilic diblock copolymer grafted with spiropyran, was prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization. The copolymer self-assembles into polymeric micelles in water and exhibits reversible dissolution and re-aggregation characteristics upon ultraviolet (UV) and visible (Vis)-light irradiation. The fluorescence response of spiropyran immobilized onto the copolymer was light switchable. When nitrobenzoxadiazolyl derivative (NBD) dyes are encapsulated into the core of the micelles, a reversible, light-responsive, dual-color fluorescence resonance energy transfer (FRET) system is constructed and processed, which is well regulated by alternatively UV/vis irradiation. We anticipate these photoswitchable and FRET lighting up nanoparticles will be useful in drug delivery and cell imaging or tracking synchronously.
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Received: 11 November 2013
Published: 24 December 2013
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| Fund: This work was financially supported by the National Natural Science Foundation of China (Nos. 51073106 and 51121001) and Program for Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China (No. IRT1026). |
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Corresponding Authors:
Si-Chong Chen, Yu-Zhong Wang
E-mail: chensichong@scu.edu.cn;yzwang@scu.edu.cn
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