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| A novel series of 2,5-disubstituted 1,3,4-thiadiazoles as potential anticonvulsant agent |
| Harish Rajaka, Chinmay K. Beheraa, Rajesh S. Pawarb, Pradeep K. Singourb, Murli Dhar Kharyac |
a SLT Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur-495 009, (C. G.), India;
b VNS Institute of Pharmacy, Neelbud, Bhopal-462 044, (M. P.), India;
c Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar-470 003, (M. P.), India |
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Abstract In pursuit for better antiepileptic drug and the importance of semicarbazones and 2, 5-disubstituted 1, 3, 4-thiadiazoles as anticonvulsant pharmacophore, a series of novel N-({5-[(6-methyl-1-benzofuran-3-yl) methyl]-1, 3, 4-thiadiazol-2-yl}carba-mothioyl)-2/3/4-substitutedbenzamide were designed, synthesized and evaluated for their anticonvulsant activity. The findings of the present studies confirmed that the pharmacophore model with four binding sites is crucial for anticonvuisant activity. Structure-activity relationships among synthesized compounds were also established.
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Received: 29 December 2009
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Corresponding Authors:
Harish Rajak,E-mail address:harishdops@yahoo.co.in
E-mail: harishdops@yahoo.co.in
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| About author:: 10.1016/j.cclet.2010.04.012 |
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Ming-Hua Chen, Sheng Lin, Ya-Nan Wang, Cheng-Gen Zhu, Yu-Huan Li, Jian-Dong Jiang, Jian-Gong Shi. Antiviral stereoisomers of 3,5-bis(2-hydroxybut-3-en-1-yl)-1,2, 4-thiadiazole from the roots of Isatis indigotica[J]. CCL, 2016, 27(05): 643-648. |
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