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| Highly efficient synthesis of 2,3-dihydroquinazolin-4 (1H)-ones catalyzed by heteropoly acids in water |
| YingXiao Zonga, Yan Zhaoa, WenCai Luoa, Xing Hai Yua, Jun Ke Wanga,b, Yi Panb |
a Key Laboratory of Resources and Environment, Chemistry of West China, Hexi University, Zhangye 734000, China;
b School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China |
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Abstract Heteropoly acids efficiently catalyzed the cyclocondensation reaction of anthranilamide with aldehydes in water at ambient temperature and afforded the corresponding 2,3-dihydro-4 (1H)-quinazolinones compounds in good to excellent yields. This method provides mild reaction conditions and clean reaction profiles, using a small quantity of catalyst and a simple workup procedure.
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Received: 20 October 2009
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| Fund:We gratefully acknowledge the financial support of Key Laboratory of Resources and Environment Chemistry of West China (No. XZ0704). |
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Corresponding Authors:
Jun Ke Wang,E-mail addresses:wangjk@hxu.edu.cn,wjkzyx@yahoo.com.cn
E-mail: wangjk@hxu.edu.cn,wjkzyx@yahoo.com.cn
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