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| N-(2-(2-Methoxyphenylthio)benzyl)-2-aryloxyethylamines: Synthesis and evaluation for dual 5-HT1A/SSRI activities |
| Xue Dan Wua, Dong Zhi Liua, Ai Jun Lia,b, Xue Qin Zhoua |
a School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;
b College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China |
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Abstract The design, synthesis and biological evaluation of N-(2-(2-methoxyphenylthio) benzyl)-2-aryloxyethyl amines with dual 5-HT1A/SSRI activities are reported. Compound 8e displays the best dual activities and is a promising lead compound for further SAR studies.
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Received: 05 November 2007
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| Fund:This work was supported by the National Natural Science Foundation of China (No. 20576094). We also thank Prof. Chen Naihong for determining affinity at the 5-HTT and 5-HT1A receptor. |
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Corresponding Authors:
Ai Jun Li,E-mail address:lajd@tju.edu.cn
E-mail: lajd@tju.edu.cn
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