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| Synthesis and biological activity of novel N-(3-furan-2-yl-1-phenyl-1H-pyrazol-5-yl) amides derivatives |
| Jing-Qian Huoa, Liu-Yong Mab, Zhe Zhanga, Zhi-Jin Fanb,c, Jin-Lin Zhanga, Tetyana V. Beryozkinad, Vasiliy A. Bakulevd |
a College of Plant Protection, Agricultural University of Hebei, Baoding 071001, China;
b State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China;
c Collaborative Innovation Center of Chemical Science and Engineering(Tianjin), Nankai University, Tianjin 300071, China;
d The Ural Federal University Named after the First President of Russia B. N. Yeltsin, Ekaterinburg 620002, Russia |
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Abstract A series of novel N-(3-furan-2-yl-1-phenyl-1H-pyrazol-5-yl) amides derivatives were designed and synthesized. Their structures were confirmed by 1H NMR, 13C NMR and HRMS. All title compounds were evaluated for their herbicidal and antifungal activities. Preliminary bioassay results indicated that the title compounds showed good to moderate herbicidal activity at 1000 mg/L. Compound 6q presented the best activity against Digitaria sanguinalis (L) Scop., Amaranthus retroflexus L. and Arabidopsis thaliana with an inhibition degree of five. Compound 6d also showed an inhibition degree of five against D. sanguinalis. In addition, at 50 mg/L, most compounds exhibited good in vitro antifungal activity against Sclerotinia sclerotiorum, with compound 6c showing over 90% antifungal activity against S. sclerotiorum and Pellicularia sasakii.
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Received: 23 May 2016
Published: 17 June 2016
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| Fund:This work was financially supported by the National Natural Science Foundation of China (Nos. 31171877, 31571991, 21372132) and the International Science & Technology Cooperation Program of China (No. 2014DFR41030). |
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