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| Chemical constituents from Cicuta virosa Linnaeus and their reversal effects on doxorubicin-resistant human myelogenous leukemia (K562/A02) cells |
| Shu-Qi Wanga, Qing-Wei Zhangb, Xiao-Ling Wangc, Xia-Xia Did, Xiao-Ning Wanga, Hong-Xiang Loua |
a School of Pharmaceutical Science, Shandong University, Jinan 250012, China;
b Xintai Institute of Skin Diseases, Xintai 271200, China;
c The Second Hospital of Shandong University, Jinan 250033, China;
d Faculty of Pharmaceutical Sciences, School of Health Sciences, University of Iceland, Iceland |
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Abstract Two new compounds, 11,11'-dimer of scopoletin (1) and 11-O-β-glucopyranosylhamaudol (2), together with seven known compounds were isolated and identified from the whole grass of Cicuta virosa. The chemical structures of the isolated compounds were elucidated using different spectroscopic methods. In addition, the chemical constituents were evaluated for multidrug resistance reversing activity towards doxorubicin-resistant K562/A02 cells. Compounds 1, 8, and 9 were endowed with remarkable MDR reversing effects.
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Received: 03 February 2016
Published: 02 April 2016
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| Fund:Financial supported from the National Natural Science Foundation of China (Nos. 81202422, 21472113, and 31500280) and the Natural Science Foundation of Shandong Province (No. ZR2012HQ024) are acknowledged. |
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Corresponding Authors:
Xiao-Ning Wang, Hong-Xiang Lou
E-mail: wangxn@sdu.edu.cn;louhongxiang@sdu.edu.cn
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