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| Polyoxygenated dihydropyrano[2,3-c]pyrrole-4,5-dione derivatives from the marine mangrove-derived endophytic fungus Penicillium brocae MA-231 and their antimicrobial activity |
| Ling-Hong Menga,b, Xiao-Ming Lia, Yang Liua,b, Bin-Gui Wanga |
a Jiangxi Key Labrotory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China;
b College of Science, Jiangxi Agricultural University, Nanchang 330045, China |
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Abstract A new polyoxygenated dihydropyrano[2,3-c]pyrrole-4,5-dione derivative, pyranonigrin F (1), together with a related known compound, pyranonigrin A (2), were isolated and identified from Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these metabolites were determined based on comprehensive spectral interpretation and the absolute configuration of compound 1 was established by X-ray crystallographic analysis. Compounds 1, and 2 showed potent activity against a broad spectrum of human-, aqua-, and plant-pathogens.
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Received: 13 November 2014
Published: 16 February 2015
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| Fund: Financial support from the National Natural Science Foundation of China (No. 31270403) and from the Ministry of Science and Technology of China (No. 2010CB833802) is gratefully acknowledged. |
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Corresponding Authors:
Bin-Gui Wang
E-mail: wangbg@ms.qdio.ac.cn
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Crystallographic data of compound 1 have been deposited in the Cambridge Crystallographic Data Centre as CCDC 1032043. The data can be obtained free of charge via http://www.ccdc.cam.ac.uk/data_request/cif (or from the CCDC, 12 Union Road, Cambridge CB21EZ, UK; fax: +44-1223-336-033; e-mail: deposit@_ccdc.cam.ac.uk).
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