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| Nickel-catalyzed cross-coupling reaction of alkynyl bromides with Grignard reagents |
| Qing-Han Li, Yong Ding, Xue-Jun Yang |
| College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041, China |
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Abstract We describe a convenient method for the synthesis of 1,2-disubstituted acetylenes via a cross-coupling reaction of (bromoethynyl)benzene with Grignard reagents. The reaction of (bromoethynyl)benzene (1 mmol) with Grignard reagent (1.3 mmol) mediated by NiCl2 (4 mol%) and (p-CH3Ph)3P (8 mol%) in THF could produce 1,2-disubstituted acetylenes in good yields at room temperature.
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Received: 31 January 2014
Published: 30 April 2014
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| Fund: This work was financially supported by the Fundamental Research Funds for the Central Universities, Southwest University for Nationalities (No. 12NZYTH03), and the Natural Science Foundation of Southwest University for Nationalities (No. 381010), and the Project of Postgraduate Degree Construction, Southwest University for Nationalities (No. 2013XWD-S0703), and the State Administration of Foreign Experts Affairs project (No. 2012-10). |
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Corresponding Authors:
Qing-Han Li
E-mail: lqhchem@163.com
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