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| Silica-bonded N-propyl sulfamic acid as an efficient recyclable catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones under heterogeneous conditions |
| Srinivasa Rao Jetti, Anjna Bhatewara, Tanuja Kadre, Shubha Jain |
| Laboratory of Heterocycles, School of Studies in Chemistry & Biochemistry, Vikram University, Ujjain, Madhya Pradesh, 456010, India |
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Abstract Silica-bonded N-propyl sulfamic acid (SBNPSA) catalyzed one-pot three component Biginelli condensation of different substituted aromatic aldehydes with ethyl acetoacetate and urea/thoiurea to the respective 3,4-dihydropyrimidin-2-(1H)-ones and thiones in environment friendly procedure is described. The facile reaction conditions, simple isolation and purification procedures of this method make it a good option for the synthesis of dihydropyrimidinones.
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Received: 14 October 2013
Published: 24 December 2013
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Corresponding Authors:
Srinivasa Rao Jetti
E-mail: srinujetti479@gmail.com
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