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| An improved synthesis of (lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptane |
| Dong-Feng Zhang, Peng Li, Zi-Yun Lin, Hai-Hong Huang |
| Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050, China |
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Abstract An improved and efficient method for synthesis of (lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptane (1) from trans-4-hydroxy-L-proline was developed. Using benzyloxycarbonyl (Cbz) as protection group of amine, the reactions were inmild conditions, and the title compound 1 was accomplished in six steps in overall yield of 70%.
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Received: 04 September 2013
Published: 07 December 2013
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Corresponding Authors:
Hai-Hong Huang
E-mail: joyce@imm.ac.cn
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