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| Simply air:Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air |
| Lu Yina, Xian Jiaa, Xing Shu Lib, Albert S. C. Chana,b |
a School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China;
b School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China |
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Abstract Vanadium-catalyzed oxidative kinetic resolution (OKR) of methyl o-chloromandelate 2a, key intermediate of the well-known oral antiplatelet agent (S)-clopidogrel, was achieved by ambient air for the first time. The air oxidation system, which was composed of vanadium and tridentate Schiff base ligands derived from amino alcohols and salicylaldehyde derivatives, afforded an efficient and economic approach to the target intermediate with high enantioselectivities (> 99% ee).
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Received: 15 August 2009
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Corresponding Authors:
Xian Jia,E-mail addresses:jiaxian206@163.com;Xing Shu Li, lixsh@mail.sysu.edu.cn
E-mail: jiaxian206@163.com;lixsh@mail.sysu.edu.cn
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