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| A mild and efficient method for nucleophilic aromatic fluorination using tetrabutylammonium fluoride as fluorinating reagent |
| Yu Feng Hu, Jun Luo, Chun Xu LÜ |
| School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, China |
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Abstract Anhydrous tetrabutylammonium fluoride(TBAFanh.)has been found to be a highly efficient fluorinating reagent for nucleophilic aromatic fluorinations such as fluorodenitration or halogen exchange(Halex)reaction.The products were formed in high to excellent yields under surprisingly mild reaction conditions and no phenol or ether side-products were detected in these reactions.
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Received: 15 June 2009
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| Fund:We are grateful to the National Basic Research (973) Program of China (No. 613740101). |
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Corresponding Authors:
Chun Xu LÜ,E-mail address:lucx@mail.njust.edu.cn
E-mail: lucx@mail.njust.edu.cn
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