One new bufadienolide biotransformed from cinobufagin by <i>Cunninghamella elegans</i>

doi:10.1016/j.cclet.2007.12.019

Abstract
Figure/Table
References
Related Citation (9)

Download: PDF (216 KB) HTML ( )
Export: BibTeX | EndNote (RIS)

Abstract Cunninghamella elegans has been employed for the biotransformation of cinobufagin (1) to afford one metabolites. The structure of the transformation product has been characterized as 7β, 12β-dihydroxylcinobufagin (2). Product 2 is a new compound. In vitro cytotoxic activities of the biotransformation product and the substrate-cinobufagin have been assayed against HeLa; they all showed cytotoxic activities.

Key words： Biotransformation Cinobufagin 7β,12β-Dihydroxylcinobufagin Cunninghamella elegans

Received: 10 September 2007

Fund:The authers thank Yi Sha and Wen Li for the measurements of NMR spectra.

Corresponding Authors: Yue Hu Pei ,E-mail address:peiyueh@vip.163.com E-mail: peiyueh@vip.163.com

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Li Qiao
	Yu Zhi Zhou
	Huan Chen
	Jia Qing Cao
	Yue Hu Pei

Cite this article:

Li Qiao,Yu Zhi Zhou,Huan Chen, et al. One new bufadienolide biotransformed from cinobufagin by Cunninghamella elegans[J]. CCL, 2008, 19(03): 299-301.

URL:

http://www.chinchemlett.com.cn/EN/10.1016/j.cclet.2007.12.019 OR http://www.chinchemlett.com.cn/EN/Y2008/V19/I03/299

[1]	Hai-Yan Li, Lian-Zhu Zhang, Shi-Hui Wang, Yue Deng, Xiang-Qun Jin. Two new bufotoxins from the skin of Bufo bufo gargarizans[J]. CCL, 2013, 24(08): 731-733.